Diablo 2 Resurrected Mephisto is the third major boss fight you'll face and the final scene in act three.This is one of the tougher bosses that you will face in the game.

Knowing how to deal with these bosses, however, will make your life considerably easier, as you can take advantage of the many customization mechanics found in Diablo II Resurrected to tweak your build to be more effective against these powerful enemies.

It's actually a bit of a reprieve following the Andariel and Duriel boss fights. Mephisto is still a big, deadly demon, but he's got fewer tricks up his bony sleeves than those who came before. Melee classes in particular finally get a chance to prove their worth in a boss fight.

Where?
You can find Mephisto in the third level of the Durance of Hell. You access the Mephisto’s lair by destroying the Compelling Orb in Travincal, which opens a portal to his hideout. Just like many lairs, his is winding and complicated, so just in case you die, make sure to get all the waypoints along the way.

Diablo 2 Resurrected Mephisto — Mephisto Guide
Mephisto is a magician, so unlike the previous two bosses, he relies almost entirely on ranged attacks. Fortunately, your battleground for this fight is much more expansive and includes four rooms.

Mephisto's attacks rely on poison, lightning, and cold, which is your sign not to use any of those elements against him.

Also, use the surrounding rooms and hallways to your benefit. Bosses tend to stay out of these rooms, which gives you a chance to catch a breather.

If you really want your fight against Mephisto to be clean, then you should fight the boss at short range, as Mephisto’s melee attacks are not particularly powerful, especially if you have cold-resistant gear equipped. No matter how you decide to fight him, avoid staying in the back room, as he can summon spirits that can make the fight more difficult. Lure Mephisto to the other rooms, and you can focus on him alone, taking it down by alternating offense and healing with potions.

Unlike Andariel or Duriel, getting close to Mephisto is key. While his Nova attacks are still a danger, Mephisto’s melee attack is weak and he doesn’t respond well to being closed in on. You can cope with the damage by using anti-cold or lightning potions, as well as resistant gear. Moreover, while all boss battles should require a good stock of potions, Nightmare and Hell level Mephisto makes them vital. After all, he becomes more and more immune to life and mana leech, meaning you can’t rely on stealing his health to survive (looking at you, Barbarians).

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